integrative database for Hypoxia associated proteins in mammals

Welcome to iHypoxia

Oxygen is vital to life on earth. Hypoxia is a condition or state in which insufficient levels of oxygen are supplied to cells or tissues, while it is associated with a wide range of conditions in human health and diseases such as cancers, cardiovascular diseases and anemia, among others. The recent development of high-throughput sequencing based omics technologies greatly advanced the large-scale identification of hypoxia-regulated proteins and the detection of candidate reference markers for diseases diagnosis and therapy. Here, we provide a database of iHypoxia (integrative database for Hypoxia associated proteins in mammals), which host the results of hypoxia regulatory proteins based on low-throughput and high-throughput identification.

In total, 158,615 quantification events on 41,482 hypoxia-regulated proteins for 5 mammals under 390 conditions were collected and integrated in the database, while the details about the samples, hypoxia experiments were also manually curated. The iHypoxia database provides simple and user-friendly interface to browse and search data, and the detailed information is organized and visualized for queries.

#1. Ensembl ID : ENSG00000100644, #2. UniProt ID : Q16665, #3. Gene name : HIF1A, #4. Protein name : hypoxia inducible factor 1 subunit alpha